Surat Attaphitaya , Keith Nehrke and James E . Melvin shrinkage isoform 5 by protein kinases A and C and cell Acute inhibition of brain - specific Na + / H + exchanger
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[PDF] [Full Text] [Abstract] , August 1, 2002; 13 (8): 2171-2177. J. Am. Soc. Nephrol. T. Igarashi, T. Sekine, J. Inatomi and G. Seki Unraveling the Molecular Pathogenesis of Isolated Proximal Renal Tubular Acidosis [PDF] [Full Text] [Abstract] , November 1, 2002; 67 (5): 1419-1429. Biol Reprod E.A. Harding, C.A. Gibb, M.H. Johnson, D.I. Cook and M.L. Day Development Developmental Changes in the Management of Acid Loads During Preimplantation Mouse [PDF] [Full Text] [Abstract] , October 1, 2006; 291 (4): R1145-R1156. Am J Physiol Regulatory Integrative Comp Physiol M. Grosell and J. Genz intestine play a role in osmoregulation Ouabain-sensitive bicarbonate secretion and acid absorption by the marine teleost fish [PDF] [Full Text] [Abstract] , January 1, 2009; 89 (1): 193-277. Physiol Rev E. K. Hoffmann, I. H. Lambert and S. F. Pedersen Physiology of Cell Volume Regulation in Vertebrates
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Acute inhibition of brain-specific Na(+)/H(+) exchanger isoform 5 by protein kinases A and C and cell shrinkage.
Little is known of the functional properties of the mammalian, brain-specific Na(+)/H(+) exchanger isoform 5 (NHE5). Rat NHE5 was stably expressed in NHE-deficient PS120 cells, and its activity was characterized using the fluorescent pH-sensitive dye 2',7'-bis(2-carboxyethyl)-5(6)-carboxyfluorescein. NHE5 was insensitive to ethylisopropyl amiloride. The transport kinetics displayed a simple Mic...
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We previously cloned an isoform Na+/H+ exchanger (NHE3), which was expressed only in intestine, kidney, and stomach. We show here the functional characteristics of NHE3 as a Na+/H+ exchanger by stably transfecting NHE3 cDNA into PS120 cells, a fibroblast cell line that lacks endogenous Na+/H+ exchangers. NHE3 was 39- and 160-fold more resistant to inhibition by amiloride and ethylisopropyl amil...
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